Synthesis of natural product-inspired compound libraries
نویسنده
چکیده
An important aim in biology research is the elucidation of the role of proteins in complex, dynamic biological systems through the selective perturbation of their function. In contrast to genetic perturbations, chemical perturbations of protein function are conditional, acute, easily tuneable and reversible. [1] Furthermore, drug development still largely depends on the availability of bioactive small molecules. Therefore, the development of small molecule modulators of protein function is one of the major research areas in the fields of Chemical Biology and Medicinal Chemistry.
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